| Abstract | OBJECTIVES: Bone mineral density (BMD) is usually normal at the time of inflammatory bowel disease (IBD) diagnosis. The purpose of this study was to evaluate the role of vitamin D metabolism in recently diagnosed IBD. METHODS: Adult subjects with recently diagnosed IBD (median 4 yr) were recruited from the University of Manitoba IBD Research Registry into the Manitoba IBD Cohort Study. Baseline BMD and serum 25-hydroxy vitamin D (25OHD) were measured in a nested subgroup of 101 subjects of whom 94 had repeat BMD measurements 2.3 +/- 0.3 yr later. RESULTS: Only a minority (22 [21.8%]) of recently diagnosed IBD participants had optimal serum 25OHD levels (75 nmol/L or greater). Serum 25OHD was positively correlated with baseline BMD for the lumbar spine, total hip, and total body (all P < 0.05). MANOVA confirmed significant between-group differences in baseline T-scores when vitamin D status was categorized according to serum 25OHD quartile (P < 0.05). Gain in total body BMD between the baseline and follow-up DXA scans was positively correlated with 25OHD (r = 0.20, P < 0.05). CONCLUSIONS: Poorer vitamin D status correlates with lower baseline BMD at all measurement sites and better vitamin D status is correlated with a gain in total body BMD. Early optimization of vitamin D may play an important role in preventing IBD-related bone disease. |
| Authors | William D Leslie, Norine Miller, Linda Rogala, Charles N Bernstein
(Affiliation: Department of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.)
|
| Journal | The American journal of gastroenterology
(Am J Gastroenterol)
Vol. 103
Issue 6
Pg. 1451-9
(Jun 2008)
ISSN: 1572-0241 United States |
| PMID | 18422819
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Vitamin D
- 25-hydroxyvitamin D
|
| Topics |
- Absorptiometry, Photon
- Adult
- Bone Density
(physiology)
- Case-Control Studies
- Cohort Studies
- Colitis, Ulcerative
(blood)
- Crohn Disease
(blood)
- Female
- Humans
- Lumbar Vertebrae
- Male
- Manitoba
- Middle Aged
- Pelvic Bones
- Vitamin D
(analogs & derivatives, blood)
|
