Efficacy and safety of cefovecin for the treatment of urinary tract infections in cats.

Abstract

OBJECTIVES:

To determine the efficacy and safety of cefovecin (Convenia); Pfizer Animal Health) in the treatment of urinary tract infections in cats.

METHOD:

A multi-centre, masked, randomised study was conducted in cats presenting with clinical signs indicative of urinary tract infections. Cephalexin (Rilexine); Virbac) administered orally twice daily at 15 mg/kg bodyweight for 14 days was compared with a single subcutaneous injection of cefovecin in cats. The primary efficacy parameter assessed was bacterial elimination of the pretreatment uropathogen.

RESULTS:

Four hundred and thirty-four cats were screened for urinary tract infections. One hundred and eighty-five cats were treated with either cefovecin (n=124) or cephalexin (n=61). Ninety-seven cats (22.2 per cent) had confirmed bacteriuria and 82 cats were included in efficacy analysis. Escherichia coli was eliminated in 76.7 per cent (23 of 30) of cefovecin-treated cats compared with 62.5 per cent (10 of 16) of cephalexin-treated cats. Cefovecin demonstrated statistical non-inferiority compared with cephalexin for bacterial elimination. There were no suspected adverse drug reactions attributable to treatment with cefovecin or cephalexin.

CLINICAL SIGNIFICANCE:

Cefovecin was demonstrated to be an effective and safe treatment for urinary tract infections.

• Authors: C A Passmore, J Sherington, M R Stegemann
• Journal: The Journal of small animal practice (J Small Anim Pract) Vol. 49 Issue 6 Pg. 295-301 (Jun 2008) ISSN: 0022-4510 [Print] England
• PMID: 18422501 (Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Cephalosporins
• cefovecin

Topics

• Administration, Oral
• Animals
• Anti-Bacterial Agents (therapeutic use)
• Cat Diseases (drug therapy)
• Cats
• Cephalosporins (therapeutic use)
• Double-Blind Method
• Escherichia coli Infections (drug therapy, veterinary)
• Female
• Injections, Subcutaneous (veterinary)
• Male
• Safety
• Treatment Outcome
• Urinary Tract Infections (drug therapy, veterinary)