[Applying Fuzheng Huayu Gantang comprehensive therapeutic program for treatment of post-hepatitis B liver cirrhosis complicated with glyco-metabolic abnormality].

Abstract

OBJECTIVE:

To study the clinical effects of Fuzheng Huayu Gantang comprehensive therapeutic program (FHGP) on post-hepatitis B liver cirrhosis associated with glyco-metabolic abnormality (LCGA).

METHODS:

The patients with LCGA enrolled in the randomized controlled clinical trial were assigned to 2 groups, the treated group (68 cases) and the control group (74 cases), they were treated respectively by FHGP and conventional TCM and Western medicine therapeutic program for 3 months. Indexes including fasting plasma glucose (FPG), 2 h postprandial plasma glucose (2 h PG), fasting insulin (FINS) were detected, homeostasis model assessment insulin resistance (HOMA-IR) was calculated, and the score of syndrome was recorded before and after treatment. Then the effects on syndrome and glyco-metabolic abnormality were evaluated through statistical analysis.

RESULTS:

Level of 2 h PG after treatment was lowered in both groups (P < 0.01), but significant difference was found in the pre-treatment to post-treatment decrement of FPG and HOMA-IR between the two groups (P < 0.05). The syndrome improving rate and the total effective rate on glyco-metabolic abnormality in the treated group were significantly better than those in the control group respectively (85.3% vs 64.9% , P < 0.01; 80.9% vs 62.2%, P < 0.05).

CONCLUSION:

FHGP has the capability to improve the syndrome and glyco-metabolic abnormality of patients with LCGA.

• Authors: Chang-Qing Zhao, Hong-Tu Gu, Yang Cheng
• Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine (Zhongguo Zhong Xi Yi Jie He Za Zhi) Vol. 28 Issue 1 Pg. 24-7 (Jan 2008) ISSN: 1003-5370 [Print] China
• PMID: 18418964 (Publication Type: English Abstract, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Blood Glucose

Topics

• Adolescent
• Adult
• Aged
• Blood Glucose (metabolism)
• Combined Modality Therapy
• Drug Therapy (methods)
• Female
• Hepatitis B, Chronic (complications)
• Humans
• Insulin Resistance
• Liver Cirrhosis (etiology, metabolism, therapy)
• Male
• Medicine, Chinese Traditional (methods)
• Middle Aged
• Phytotherapy (methods)
• Treatment Outcome