Dose-dependent anticonvulsive effect of ethanol on lindane-induced seizures in rats.
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| Abstract |
Chronic ethanol consumption is a major risk factor for epilepsy, and seizures frequently occur during the withdrawal period. The aim of our study was to investigate effects of ethanol on lindane-induced seizures in rats. Male Wistar rats were injected i.p. with one of the following 5 treatments: (i) saline, (ii) dimethylsulfoxide, (iii) lindane (8 mg/kg) (L), (iv) ethanol in doses of 0.5 g/kg (E(0.5)), 1 g/kg (E(1)), and 2 g/kg (E(2)), and (v) groups that received ethanol 30 min before lindane (LE(0.5), LE(1), and LE(2)). Behavioral changes were described by using a descriptive scale as follows: 0, no response; 1, head nodding, lower jaw twitching; 2, myoclonic body jerks, bilateral forelimb clonus; 3, generalized tonic-clonic convulsions; 4, status epilepticus. The incidence of convulsions in the LE(2) group was significantly lower than the incidence in the L (p < 0.01) and LE(0.5) groups (p < 0.05). The median grade of convulsive behavior was significantly lower in the LE(2) (p < 0.01) and LE(1) groups (p < 0.05) compared with the L group. Latencies to the first seizure response were not significantly different among groups. ED50 of ethanol was 1.40 (1.19-1.65). Our findings suggest that ethanol decreased severity and incidence of lindane-induced seizures in a dose-dependent manner.
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| Authors | Dusan Mladenović, Dragan Hrncić, Tatjana Radosavljević, Danijela Vucević, Dragan Djurić, Aleksandra Rasić-Marković, Djuro Macut, Veselinka Susić, Ljiljana Sćepanović, Olivera Stanojlović |
| Journal | Canadian journal of physiology and pharmacology (Can J Physiol Pharmacol) Vol. 86 Issue 4 Pg. 148-52 (Apr 2008) ISSN: 0008-4212 [Print] Canada |
| PMID | 18418422 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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