[Acute interstitial nephritis of fluindione: about three cases].

Abstract

Acute interstitial nephritis is a frequent cause of acute renal failure, representing about 10% of all biopsied cases. Early recognition of drug-induced acute immunoallergic interstitial nephritis prevents the development of severe chronic renal injury. The list of imputable drugs includes phenindione, a vitamin K antagonist. Fluindione which is also an indanedione derivative is another vitamin K antagonist. We report three biopsy-proved cases of fluindione related acute interstitial nephritis with recovery of renal function after drug withdrawal and prednisone therapy.

• Authors: Christine Beauchamp, Ioana Enache, Abraham Haskour, Laurent Martin
• Journal: Nephrologie & therapeutique (Nephrol Ther) Vol. 4 Issue 5 Pg. 339-46 (Oct 2008) ISSN: 1769-7255 [Print] France
• Vernacular Title: Néphropathie interstitielle aiguë à la fluindione: à propos de trois cas.
• PMID: 18417438 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Anticoagulants
• Diuretics
• Vitamin K
• Phenindione
• fluindione

Topics

• Acute Disease
• Acute Kidney Injury (drug therapy)
• Aged
• Anticoagulants (adverse effects)
• Diuretics (therapeutic use)
• Humans
• Kidney Function Tests
• Male
• Nephritis, Interstitial (chemically induced)
• Phenindione (adverse effects, analogs & derivatives)
• Treatment Outcome
• Vitamin K (antagonists & inhibitors)