Oral myofibromas: report of two cases and review of clinical and histopathologic differential diagnosis.

Abstract

Myofibroma is a benign mesenchymal neoplasm composed of myofibroblasts which has been described with different synonyms since the first report in 1951. It may show clinical and histologic features that may be misinterpreted as a malignancy. We describe 2 cases of oral myofibromas affecting infants; the first one showed a rapid growth with teeth displacement and ulceration; the second one presented a relatively slow growth with an indolent course. Differential diagnosis included benign and malignant mesenchymal neoplasms, salivary gland tumors, and reactive processes. Microscopic analysis of both lesions revealed a spindle cell tumor with immunoreactivity for vimentin, muscle-specific actin, and specific smooth muscle isoform alpha-actin, rendering the diagnoses of myofibroma. The patients were treated with surgical excision, and both are in follow-up without any signs of recurrence. Myofibroma presents a wide range of differential diagnosis, including benign and malignant neoplasms. Therefore, accurate diagnosis may avoid an unnecessary aggressive therapy.

• Authors: Rebeca de Souza Azevedo, Fábio Ramôa Pires, Ricardo Della Coletta, Oslei Paes de Almeida, Luiz Paulo Kowalski, Márcio Ajudarte Lopes
• Journal: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics (Oral Surg Oral Med Oral Pathol Oral Radiol Endod) Vol. 105 Issue 6 Pg. e35-40 (Jun 2008) ISSN: 1528-395X [Electronic] United States
• PMID: 18417385 (Publication Type: Case Reports, Journal Article)

Chemical References

• Actins
• Vimentin

Topics

• Actins (analysis)
• Child
• Diagnosis, Differential
• Gingival Neoplasms (chemistry, pathology)
• Humans
• Immunohistochemistry
• Lip Neoplasms (chemistry, pathology)
• Male
• Myofibroma (chemistry, pathology)
• Vimentin (analysis)