Angiotensin-(1-7): pharmacological properties and pharmacotherapeutic perspectives.

Abstract

Therapeutic modulation of the renin-angiotensin system is not complete without taking into consideration the beneficial effects of angiotensin-(1-7) in cardiovascular pathology. Various pharmacological pathways are already exploited to involve this heptapeptide in therapy as both inhibitors of angiotensin-converting enzyme and angiotensin II type 1 receptor blockers increase its levels. These drugs and administered angiotensin-(1-7) elicit various common effects, and some effects of the drugs are partially mediated by angiotensin-(1-7). The pharmacodynamic profile of angiotensin-(1-7) is rather complex, and in vitro and in vivo studies demonstrated a wide palette of effects for angiotensin-(1-7), some of them potentially beneficial for cardiovascular disease. Using various animal models to study cardiovascular physiology and disease it was shown that angiotensin-(1-7) has antihypertensive, antihypertrophic, antifibrotic and antithrombotic properties, all properties that may prove beneficial in a clinical setting. We also observed a novel action of angiotensin-(1-7), namely its capacity to stimulate the proliferation of endothelial progenitor cells. Access of angiotensin-(1-7) to the clinic, however, is restricted due to its unfavorable pharmacokinetic properties. In order to benefit of the therapeutic potential of angiotensin-(1-7) it is crucial to increase its half-life, either by using more stable analogues, which are now under development, or specific delivery methods. We here review the pharmacological characteristics and therapeutic potential of angiotensin-(1-7), implementing the experimental strategies taken to exploit the pharmacological mechanism of this heptapeptide in a clinical setting, and present our contribution to this field of research.

• Authors: Dilek Iusuf, Robert H Henning, Wiek H van Gilst, Anton J M Roks
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 585 Issue 2-3 Pg. 303-12 (May 13 2008) ISSN: 0014-2999 [Print] Netherlands
• PMID: 18417117 (Publication Type: Journal Article, Review)

Chemical References

• Antihypertensive Agents
• Peptide Fragments
• Angiotensin I
• angiotensin I (1-7)

Topics

• Angiotensin I (pharmacokinetics, pharmacology, therapeutic use)
• Animals
• Antihypertensive Agents (pharmacology, therapeutic use)
• Bone Marrow Cells (drug effects)
• Diabetes Mellitus (drug therapy)
• Heart Diseases (drug therapy)
• Humans
• Hypertension (drug therapy)
• Peptide Fragments (pharmacokinetics, pharmacology, therapeutic use)
• Renin-Angiotensin System (drug effects)
• Ventricular Remodeling (drug effects)