Polynucleotide kinase 3' phosphatase variant, dietary variables and risk of adenoma recurrence in the Polyp Prevention Trial.

Abstract

Polymorphisms in a number of genes encoding for DNA repair enzymes have been associated with altering the function of these enzymes and increasing risk of a number of cancers, including colon cancer. We have investigated the association between a common variant in polynucleotide kinase 3' phosphatase (PNKP), a putative DNA repair enzyme, and risk of adenoma recurrence in the Polyp Prevention Trial participants. We also investigated possible interaction or effect modification between carriage of the variant allele, dietary components and risk of adenoma recurrence. Unconditional logistic regression models were used to calculate the odds ratios and 95% confidence intervals for an association between the G/T polymorphism, PNKP T5644G and risk of adenoma recurrence. We observed no association between carriage of the variant allele and risk of adenoma recurrence. Furthermore, we found no effect modification between genotype, dietary components and risk of adenoma recurrence. The PNKP T5644G variant does not seem to be involved in adenoma recurrence in the Polyp Prevention Trial.

• Authors: Gwen Murphy, Leah S Sansbury, Andrew W Bergen, Zhuoqiao Wang, Arthur Schatzkin, Teresa Lehman, Aravind Kalidindi, Rama Modali, Elaine Lanza
• Journal: European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) (Eur J Cancer Prev) Vol. 17 Issue 3 Pg. 287-90 (Jun 2008) ISSN: 1473-5709 [Electronic] England
• PMID: 18414202 (Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, N.I.H., Intramural, Research Support, Non-U.S. Gov't)

Chemical References

• PNKP protein, human
• Phosphotransferases (Alcohol Group Acceptor)
• Phosphoric Monoester Hydrolases
• DNA Repair Enzymes

Topics

• Adenoma (genetics, prevention & control)
• Aged
• Colonic Neoplasms (genetics, prevention & control)
• Colonic Polyps (etiology, genetics, pathology)
• DNA Repair Enzymes (genetics)
• Diet (adverse effects)
• Feeding Behavior (physiology)
• Female
• Genetic Predisposition to Disease
• Genotype
• Humans
• Male
• Middle Aged
• Neoplasm Recurrence, Local (genetics, prevention & control)
• Phosphoric Monoester Hydrolases (genetics)
• Phosphotransferases (Alcohol Group Acceptor) (genetics)
• Polymorphism, Single Nucleotide (physiology)