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The protective effect of bergamot oil extract on lecitine-like oxyLDL receptor-1 expression in balloon injury-related neointima formation.

Abstract
Lectin-like oxyLDL receptor-1 (LOX-1) has recently been suggested to be involved in smooth muscle cell (SMC) proliferation and neointima formation in injured blood vessels. This study evaluates the effect of the nonvolatile fraction (NVF), the antioxidant component of bergamot essential oil (BEO), on LOX-1 expression and free radical generation in a model of rat angioplasty. Common carotid arteries injured by balloon angioplasty were removed after 14 days for histopathological, biochemical, and immunohistochemical studies. Balloon injury led to a significant restenosis with SMC proliferation and neointima formation, accompanied by increased expression of LOX-1 receptor, malondialdehyde and superoxide formation, and nitrotyrosine staining. Pretreatment of rats with BEO-NVF reduced the neointima proliferation together with free radical formation and LOX-1 expression in a dose-dependent manner. These results suggest that natural antioxidants may be relevant in the treatment of vascular disorders in which proliferation of SMCs and oxyLDL-related endothelial cell dysfunction are involved.
AuthorsVincenzo Mollace, Salvatore Ragusa, Iolanda Sacco, Carolina Muscoli, Francesca Sculco, Valeria Visalli, Ernesto Palma, Saverio Muscoli, Luigi Mondello, Paola Dugo, Domenicantonio Rotiroti, Francesco Romeo
JournalJournal of cardiovascular pharmacology and therapeutics (J Cardiovasc Pharmacol Ther) Vol. 13 Issue 2 Pg. 120-9 (Jun 2008) ISSN: 1074-2484 [Print] United States
PMID18413898 (Publication Type: Journal Article)
Chemical References
  • Antioxidants
  • Free Radicals
  • OLR1 protein, rat
  • Plant Oils
  • Scavenger Receptors, Class E
  • Superoxides
  • bergamot oil
Topics
  • Angioplasty, Balloon (adverse effects)
  • Animals
  • Antioxidants (administration & dosage, pharmacology)
  • Carotid Stenosis (etiology, prevention & control)
  • Cell Proliferation (drug effects)
  • Dose-Response Relationship, Drug
  • Free Radicals (metabolism)
  • Gene Expression Regulation (drug effects)
  • Male
  • Muscle, Smooth, Vascular (cytology, metabolism)
  • Oxidative Stress (drug effects)
  • Plant Oils (administration & dosage, pharmacology)
  • Rats
  • Rats, Wistar
  • Scavenger Receptors, Class E (drug effects, genetics)
  • Superoxides (metabolism)
  • Tunica Intima (pathology)

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