Abstract | PROBLEM: METHODS: RESULTS: There is new evidence suggesting that tight glycemic control and earlier initiation of insulin therapy can improve outcomes in obese patients with type 2 diabetes, thereby reducing the risk for the development of both macrovascular and microvascular complications of the disease. Insulin also appears to exhibit anti-inflammatory effects, which may provide additional protection against the development of atherosclerosis. Despite the benefits of insulin therapy, many patients and physicians remain reluctant to start insulin due to concerns about weight gain. CONCLUSION: Newer insulin formulations can effectively improve glycemic control without significant effects on patient weight and, therefore, may be particularly useful in patients who are overweight or obese. Implementation of comprehensive treatment regimens that emphasize dietary modification, physical activity, and exercise, and aggressive use of pharmacological agents to achieve tight glycemic control through physiological regimens offer the most promise for reducing long-term complications in obese patients with type 2 diabetes.
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Authors | A Enrique Caballero |
Journal | Journal of diabetes and its complications
(J Diabetes Complications)
2009 Mar-Apr
Vol. 23
Issue 2
Pg. 143-52
ISSN: 1873-460X [Electronic] United States |
PMID | 18413192
(Publication Type: Journal Article, Review)
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Chemical References |
- Blood Glucose
- Hypoglycemic Agents
- Insulin
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Topics |
- Adult
- Blood Glucose
(drug effects, metabolism)
- Diabetes Mellitus, Type 2
(complications, drug therapy)
- Diabetic Angiopathies
(prevention & control)
- Exercise
- Humans
- Hypoglycemic Agents
(therapeutic use)
- Insulin
(therapeutic use)
- Nutritional Status
- Obesity
(complications)
- Overweight
(complications)
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