We report two cases of recurrent
colorectal cancer in two patients who were treated successfully with a combined oral chemotherapeutic agent folinate/
tegafur/
uracil (UFT/LV) dosage. The first case was a 74-year-old woman who underwent Hartmann operation for
colon cancer perforation. One year and 7 months after surgery, a local recurrence was found on the CT scan and endoscopy. It ended in exploratory
laparotomy though we were operated on.
Chemotherapy using
5-fluorouracil/
Leucovorin (5-FU/LV) was performed six times. Sequentially, UFT/LV internal use was managed at our outpatient clinic. This patient has been living without side effects in the first three postoperative years, and without increase in
tumors. The second case was a 65-year-old woman who underwent
abdominoperineal resection of the rectum for
rectal cancer. The histologic stage of disease aggravation of the patient was stageI. Post operatively, 2 years and 6 months later, we recognized a
metastasis node on the lung upper right lobe of the patient and her CA19-9 value climbed dramatically. The patient took UFT/LV during outpatient visits to the hospital, the lung node shadow disappeared two months later, and CA19-9 decreased, too. The patient is living without a
cancer recurrence now. UFT/LV treatment is one of the effective modalities against recurrence of
colorectal cancer from outpatient treatment while maintaining QOL.