[Effective treatment with oral administration of UFT and leucovorin (Uzel) in a patient with liver metastasis and peritoneal dissemination from cecal cancer].

Abstract

A 70-year-old woman had been diagnosed with advanced cecal cancer with liver metastasis. She had initially undergone a right hemicolectomy for cecal cancer. Although secondary surgery for liver metastasis was performed 2 months after initial surgery, the intra-operative findings showed peritoneal dissemination of diaphragm and ligament teres and liver metastasis, making curative resection impossible. Therefore , combination oral administration of UFT and LV (Uzel) was started (UFT 300 mg/day, LV 75 mg/day, 4 weeks of therapy followed by a 1-week treatment break). Two months after 4 courses, the liver metastasis had markedly diminished and CEA was within the normal range. A good complete response of the liver metastasis was achieved. In conclusion, this treatment was convenient and effective.

• Authors: Kenji Mimatsu, Atsushi Kawasaki, Osamu Aramaki, Youichi Kuboi, Sadao Amano, Takatsugu Oida
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 35 Issue 4 Pg. 653-5 (Apr 2008) ISSN: 0385-0684 [Print] Japan
• PMID: 18408438 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Tegafur
• Uracil
• Leucovorin

Topics

• Administration, Oral
• Aged
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use)
• Cecal Neoplasms (drug therapy, pathology, surgery)
• Female
• Humans
• Leucovorin (administration & dosage, therapeutic use)
• Liver Neoplasms (drug therapy, secondary, surgery)
• Tegafur (administration & dosage, therapeutic use)
• Tomography, X-Ray Computed
• Uracil (administration & dosage, therapeutic use)