Abstract |
The synthesis of a simple analogue of salicylihalamide A with a truncated lactone ring (+/- 2) was achieved in 10 steps. Its cytotoxicity profile in the NCI 60-cell-line human tumor assay differed significantly from that of salicylihalamide A in both level and specificity.
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Authors | Shaoshan Tang, Karen L Erickson |
Journal | Journal of natural products
(J Nat Prod)
Vol. 71
Issue 5
Pg. 898-901
(May 2008)
ISSN: 0163-3864 [Print] United States |
PMID | 18407694
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Antineoplastic Agents
- Bridged Bicyclo Compounds, Heterocyclic
- salicylihalamide A
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Topics |
- Animals
- Antineoplastic Agents
(chemical synthesis, chemistry, pharmacology)
- Bridged Bicyclo Compounds, Heterocyclic
(chemical synthesis, chemistry, pharmacology)
- Drug Screening Assays, Antitumor
- Humans
- Molecular Structure
- Porifera
(chemistry)
- Stereoisomerism
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