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Synthesis and cytotoxicity of a salicylihalamide A analogue.

Abstract
The synthesis of a simple analogue of salicylihalamide A with a truncated lactone ring (+/- 2) was achieved in 10 steps. Its cytotoxicity profile in the NCI 60-cell-line human tumor assay differed significantly from that of salicylihalamide A in both level and specificity.
AuthorsShaoshan Tang, Karen L Erickson
JournalJournal of natural products (J Nat Prod) Vol. 71 Issue 5 Pg. 898-901 (May 2008) ISSN: 0163-3864 [Print] United States
PMID18407694 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
Chemical References
  • Antineoplastic Agents
  • Bridged Bicyclo Compounds, Heterocyclic
  • salicylihalamide A
Topics
  • Animals
  • Antineoplastic Agents (chemical synthesis, chemistry, pharmacology)
  • Bridged Bicyclo Compounds, Heterocyclic (chemical synthesis, chemistry, pharmacology)
  • Drug Screening Assays, Antitumor
  • Humans
  • Molecular Structure
  • Porifera (chemistry)
  • Stereoisomerism

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