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MGN-3/Biobran, modified arabinoxylan from rice bran, sensitizes human breast cancer cells to chemotherapeutic agent, daunorubicin.

AbstractBACKGROUND:
MGN-3/Biobran, a modified form of arabinoxylan from rice bran, is a potent biological response modifier (BRM). Our previous studies demonstrated that MGN-3 sensitizes human leukemia cells to death receptor [CD95]-induced apoptosis [Ghoneum M, Gollapudi S. MGN-3 sensitizes human T cell leukemia cells to death receptor (CD95)-induced apoptosis. Cancer Lett 2003;201:41-9]. In this study, we evaluated the chemo-sensitizing activity of MGN-3 against human breast cancer cells (BCCs) in vitro.
METHODS:
BCCs (MCF-7 and HCC70 cells) were cultured with different concentrations of daunorubicin (DNR) (from 1x10(-9) to 1x10(-6)M) in the presence or absence of selected concentrations of MGN-3 (100-1000mug/ml) for 3 days. Cancer cell survival was determined by MTT assay and drug accumulation was determined by flow cytometry.
RESULTS:
Treatment with MGN-3 increased susceptibility of BCCs to DNR (5.5-fold for MCF-7 and 2.5-fold for HCC70 cells) as compared to BCCs treated with DNR alone. The sensitizing effect of MGN-3 was associated with increased accumulation of DNR in cancer cells.
CONCLUSIONS:
Our data demonstrate that MGN-3 is an effective chemo-sensitizer and may represent a potential novel adjuvant for the treatment of breast cancer.
AuthorsSastry Gollapudi, Mamdooh Ghoneum
JournalCancer detection and prevention (Cancer Detect Prev) Vol. 32 Issue 1 Pg. 1-6 ( 2008) ISSN: 1525-1500 [Electronic] England
PMID18406070 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents
  • Xylans
  • polysaccharide MGN3
  • Daunorubicin
Topics
  • Antineoplastic Agents (therapeutic use)
  • Breast Neoplasms (drug therapy)
  • Cell Line, Tumor
  • Cell Survival
  • Chemotherapy, Adjuvant
  • Daunorubicin (pharmacokinetics, therapeutic use)
  • Dose-Response Relationship, Drug
  • Drug Synergism
  • Humans
  • Xylans (therapeutic use)

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