HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Intravitreal anti-VEGF therapy for capillary hemangioblastomas in von Hippel-Lindau disease].

AbstractBACKGROUND:
Up-regulated expression of the vascular endothelial growth factor (VEGF) in von Hippel-Lindau (VHL) disease has been postulated to induce retinal hemangioblastoma. Intravitreal injections of anti-VEGF drugs might provide a new therapeutic option in this condition.
METHODS:
In a single case decision a patient with active retinal hemangioblastomas due to VHL disease received repeated intravitreal injections of 0.5 mg ranibizumab.
RESULTS:
Subsequent to intravitreal anti-VEGF therapy, the signs of activity of the retinal hemangioblastomas slowly regressed.
CONCLUSIONS:
Intravitreal anti-VEGF therapy might, as monotherapy or as combination therapy, offer a new treatment option for retinal hemangioblastoma.
AuthorsS Michels, E Messmer, F Sutter, M M Kurz-Levin
JournalKlinische Monatsblatter fur Augenheilkunde (Klin Monbl Augenheilkd) Vol. 225 Issue 4 Pg. 292-4 (Apr 2008) ISSN: 0023-2165 [Print] Germany
Vernacular TitleIntravitreale anti-VEGF-Therapie von retinalen kapillären Hämangioblastomen bei von-Hippel-Lindau-Erkrankung.
PMID18401796 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Humanized
  • Vascular Endothelial Growth Factor A
  • Ranibizumab
Topics
  • Adult
  • Antibodies, Monoclonal (administration & dosage)
  • Antibodies, Monoclonal, Humanized
  • Drug Administration Schedule
  • Endothelium, Vascular (drug effects)
  • Female
  • Hemangioblastoma (blood supply, drug therapy)
  • Humans
  • Injections
  • Ophthalmoscopes
  • Ranibizumab
  • Retinal Neoplasms (blood supply, drug therapy)
  • Vascular Endothelial Growth Factor A (antagonists & inhibitors)
  • Visual Acuity (drug effects)
  • Vitreous Body
  • von Hippel-Lindau Disease (drug therapy)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: