Involvement of ionotropic glutamate receptors in the appearance of arecoline tremor in mice.

Abstract

Administration of the muscarinic cholinoreceptor agonist arecoline (6 mg/kg, s.c.) to mice induced long-lasting tremor. The ability of non-competitive antagonists of ionotropic glutamate receptors to suppress the onset of tremor was studied. These antagonists, i.e., adamantane and phenylcyclohexyl derivatives, selectively blocked NMDA-type receptor channels (monocations) or both NMDA-and AMPA-type channels (dications). Both types of blocker weakened arecoline tremor, though the dose-response relationships were different for mono-and dications. The effects of dications appeared only at low blocker doses (0.0001-0.01 micromol/kg) but gradually disappeared on dose elevation. These data lead to the conclusion that the mechanism of pathogenesis of arecoline tremor predominantly involves NMDA-type receptors. Moderate blockade of AMPA-type receptors could potentiate the preventive effect of mixed-action antagonists (anti-NMDA+anti-AMPA), though predominance of blocking action against AMPA-type receptors prevented this effect.

• Authors: N Ya Lukomskaya, V V Lavrent'eva, L A Starshinova, E P Zhabko, V E Gmiro, L G Magazanik
• Journal: Neuroscience and behavioral physiology (Neurosci Behav Physiol) Vol. 38 Issue 4 Pg. 421-6 (May 2008) ISSN: 0097-0549 [Print] United States
• PMID: 18401736 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cyclohexylamines
• Excitatory Amino Acid Antagonists
• Quaternary Ammonium Compounds
• Receptors, AMPA
• Receptors, N-Methyl-D-Aspartate
• Arecoline
• Adamantane

Topics

• Adamantane (analogs & derivatives, pharmacology)
• Animals
• Arecoline
• Cyclohexylamines (pharmacology)
• Excitatory Amino Acid Antagonists (pharmacology)
• Mice
• Quaternary Ammonium Compounds (pharmacology)
• Receptors, AMPA (drug effects, metabolism)
• Receptors, N-Methyl-D-Aspartate (drug effects, metabolism)
• Tremor (chemically induced, metabolism, prevention & control)