Abstract | OBJECTIVE: STUDY DESIGN: The search strategy of the Cochrane Neonatal Review Group was used. The following databases were searched: Medline, Cochrane Central Register of Controlled Trials, CINAHL and EMBASE. In addition, we hand-searched abstracts of Pediatric Academic Societies annual meetings published in Pediatric Research (1990 to July 2007) and Canadian Pediatric Society annual meeting proceedings (1990 to July 2007). No language restrictions were applied. Included were randomized controlled trials of antibiotics given prophylactically to prevent infection in preterm infants (<37 completed weeks) less than 1-month old admitted to neonatal intensive care units. Both centrally or peripherally inserted central venous catheters were included. Assessment of methodological quality and extraction of data for included trials was undertaken independently by two authors. When suitable, data from trials were combined in a meta-analysis. RESULT: CONCLUSION: Prophylactic vancomycin appeared to be effective in preventing catheter-related sepsis in preterm neonates. The potential risks, however, of the emergence of resistance because of prophylactic antibiotics, and their continued effectiveness, need further evaluation, before routine use can be recommended.
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Authors | A Lodha, A D Furlan, H Whyte, A M Moore |
Journal | Journal of perinatology : official journal of the California Perinatal Association
(J Perinatol)
Vol. 28
Issue 8
Pg. 526-33
(Aug 2008)
ISSN: 1476-5543 [Electronic] United States |
PMID | 18401350
(Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)
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Topics |
- Antibiotic Prophylaxis
- Bacteremia
(prevention & control)
- Catheterization, Central Venous
(adverse effects)
- Catheters, Indwelling
(microbiology)
- Humans
- Infant, Newborn
- Infant, Premature
- Infant, Premature, Diseases
(prevention & control)
- Intensive Care, Neonatal
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