Anti-
tumor preventative effect of mono-
therapy with the use of Proteus
vaccine, Staphylococcus
antitoxin and divaccine of Staphylococcus-Proteus has been studied. Experiments were carried out on 80 non-purebred laboratory white mice (age--3-3,5 months, body mass--18-20 g) and 60 rats (body mass--100-120 g) using intraperitoneal inoculation of Ehrlich's
adenocarcinoma (ascitic form--EAT, in mice,
cancer cells--3 x 10(6)), and subcutaneous inoculation of
Sarcoma S-45 (in rats). Anti-
tumor preventative effect of
bacterial vaccines and immunization was evaluated according to the following parameters: Frequency of
cancer development, Inhibition of
cancer growth, Body mass index of experimental animals, Volume of ascitic fluid. Results of experiments have shown that use of
bacterial polysaccharides with preventative purposes has better effect at S-45 growth than at EAT growth; Vaccination with Proteus prolongs lifespan mach more than vaccination with
antitoxin of Staphylococcus; Vaccination with complex divaccine of Staphylococcus-Proteus causes complete resorption of
tumors from 32 to 60 days; Development of experimental malignant
tumors depends on type of anti-microbial
vaccines and starting date of inoculation after completion of vaccination.