Abstract |
We studied the effect of Mg- L-aspartate, MgCL2, and their combinations with vitamin B6, magneB6, and MgSO4 on seizure threshold in rats with dietary Mg2+ deficiency. Mg2+ deficiency was followed by a decrease in the threshold dose of corazol (from 79.20 to 49.48 mg/kg), shortening of the latency of the first jerk (by 33.6%, p=0.012), and reduction of the time to the first episode of clonic seizures (by 32.6%, p=0.011). Seizure threshold and latencies of the first jerk and first episode of clonic seizures increased over 3 weeks after peroral administration of Mg2+ salts. The combination of Mg2+ salts and pyridoxine was most effective in this respect.
|
Authors | A A Spasov, I N Iezhitsa, M V Kharitonova, M S Kravchenko |
Journal | Bulletin of experimental biology and medicine
(Bull Exp Biol Med)
Vol. 144
Issue 2
Pg. 214-6
(Aug 2007)
ISSN: 0007-4888 [Print] United States |
PMID | 18399283
(Publication Type: Journal Article)
|
Chemical References |
- Anticonvulsants
- Magnesium Chloride
- Aspartic Acid
- Pyridoxine
- Pentylenetetrazole
|
Topics |
- Animals
- Anticonvulsants
(administration & dosage, pharmacology)
- Aspartic Acid
(administration & dosage, pharmacology)
- Magnesium Chloride
(administration & dosage, pharmacology)
- Magnesium Deficiency
(drug therapy, physiopathology)
- Male
- Pentylenetetrazole
(toxicity)
- Pyridoxine
(administration & dosage)
- Rats
- Seizures
(chemically induced, drug therapy, physiopathology)
|