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Effect of magnesium chloride and magnesium L-aspartate on seizure threshold in rats under conditions of dietary magnesium deficiency.

Abstract
We studied the effect of Mg-L-aspartate, MgCL2, and their combinations with vitamin B6, magneB6, and MgSO4 on seizure threshold in rats with dietary Mg2+ deficiency. Mg2+ deficiency was followed by a decrease in the threshold dose of corazol (from 79.20 to 49.48 mg/kg), shortening of the latency of the first jerk (by 33.6%, p=0.012), and reduction of the time to the first episode of clonic seizures (by 32.6%, p=0.011). Seizure threshold and latencies of the first jerk and first episode of clonic seizures increased over 3 weeks after peroral administration of Mg2+ salts. The combination of Mg2+ salts and pyridoxine was most effective in this respect.
AuthorsA A Spasov, I N Iezhitsa, M V Kharitonova, M S Kravchenko
JournalBulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 144 Issue 2 Pg. 214-6 (Aug 2007) ISSN: 0007-4888 [Print] United States
PMID18399283 (Publication Type: Journal Article)
Chemical References
  • Anticonvulsants
  • Magnesium Chloride
  • Aspartic Acid
  • Pyridoxine
  • Pentylenetetrazole
Topics
  • Animals
  • Anticonvulsants (administration & dosage, pharmacology)
  • Aspartic Acid (administration & dosage, pharmacology)
  • Magnesium Chloride (administration & dosage, pharmacology)
  • Magnesium Deficiency (drug therapy, physiopathology)
  • Male
  • Pentylenetetrazole (toxicity)
  • Pyridoxine (administration & dosage)
  • Rats
  • Seizures (chemically induced, drug therapy, physiopathology)

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