Safety of a fifth dose of diphtheria and tetanus toxoid and acellular pertussis vaccine in children experiencing extensive, local reactions to the fourth dose.

Abstract	Extensive local reactions have been reported after booster doses of diphtheria and tetanus toxoid and acellular pertussis vaccine, but few data are available on revaccination after these reactions. Of 20 children with extensive local reactions after dose 4, only 4 experienced entire upper arm swelling and 7 had swelling >5 cm after dose 5. These reactions were well tolerated and support revaccination.
Authors	Margaret B Rennels, Steven Black, Emily Jane Woo, Scott Campbell, Kathryn M Edwards
Journal	The Pediatric infectious disease journal (Pediatr Infect Dis J) Vol. 27 Issue 5 Pg. 464-5 (May 2008) ISSN: 0891-3668 [Print] United States
PMID	18398385 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References	Diphtheria-Tetanus-acellular Pertussis Vaccines
Topics	Arm (pathology) Child Child, Preschool Diphtheria-Tetanus-acellular Pertussis Vaccines (adverse effects) Humans Immunization, Secondary (adverse effects)

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