3-Hydroxy-3-methylglutaric acid and triton-induced hyperlipidemia in rats.

Abstract

3-Hydroxy-3-methylglutaric acid (HMG) significantly decreased cholesterol, triglyceride and phospholipid levels in whole serum, serum beta-lipoproteins and liver of Triton-induced hyperlipidemic rats. Therapeutically 50 mg HMG/kg is equivalent to 200 mg nicotinic acid/kg in lowering all these lipid parameters. HMG may exert its hypolipidemic effect through inhibition of lipoprotein synthesis.

• Authors: S Y Yousufzai, M Siddiqi
• Journal: Experientia (Experientia) Vol. 32 Issue 9 Pg. 1178-9 (Sep 15 1976) ISSN: 0014-4754 [Print] Switzerland
• PMID: 183980 (Publication Type: Journal Article)

Chemical References

• Anticholesteremic Agents
• Glutarates
• Hydroxy Acids
• Lipoproteins, LDL
• Nicotinic Acids
• Phospholipids
• Quaternary Ammonium Compounds
• Triglycerides
• Polyethylene Glycols
• Cholesterol

Topics

• Animals
• Anticholesteremic Agents (therapeutic use)
• Cholesterol (analysis, blood)
• Glutarates (therapeutic use)
• Hydroxy Acids (therapeutic use)
• Hyperlipidemias (chemically induced, prevention & control)
• Lipoproteins, LDL (blood)
• Liver (analysis, drug effects)
• Male
• Nicotinic Acids (pharmacology)
• Phospholipids (analysis, blood)
• Polyethylene Glycols
• Quaternary Ammonium Compounds
• Rats
• Triglycerides (analysis, blood)