Abstract |
Here, recent insights into iron homeostasis are highlighted. Three studies demonstrate the importance of the IRE-IRP system for enterocytes in balancing extracellular iron demand against cellular iron requirements, show that the hemochromatosis protein HFE exerts its iron-regulatory activity principally in hepatocytes by modulating the production of hepcidin, and provide strong support for a proposed mechanism of transcriptional regulation of hepcidin through a signaling cascade initiated by holotransferrin displacing HFE from transferrin receptor 1.
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Authors | Tomas Ganz |
Journal | Cell metabolism
(Cell Metab)
Vol. 7
Issue 4
Pg. 288-90
(Apr 2008)
ISSN: 1550-4131 [Print] United States |
PMID | 18396134
(Publication Type: Journal Article, Review)
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Chemical References |
- Antimicrobial Cationic Peptides
- HAMP protein, human
- HFE protein, human
- Hemochromatosis Protein
- Hepcidins
- Histocompatibility Antigens Class I
- Membrane Proteins
- Receptors, Transferrin
- Iron
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Topics |
- Animals
- Antimicrobial Cationic Peptides
(metabolism)
- Hemochromatosis
(genetics, metabolism)
- Hemochromatosis Protein
- Hepatocytes
(metabolism)
- Hepcidins
- Histocompatibility Antigens Class I
(metabolism)
- Homeostasis
- Humans
- Iron
(metabolism)
- Membrane Proteins
(metabolism)
- Receptors, Transferrin
(metabolism)
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