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Iron homeostasis: fitting the puzzle pieces together.

Abstract
Here, recent insights into iron homeostasis are highlighted. Three studies demonstrate the importance of the IRE-IRP system for enterocytes in balancing extracellular iron demand against cellular iron requirements, show that the hemochromatosis protein HFE exerts its iron-regulatory activity principally in hepatocytes by modulating the production of hepcidin, and provide strong support for a proposed mechanism of transcriptional regulation of hepcidin through a signaling cascade initiated by holotransferrin displacing HFE from transferrin receptor 1.
AuthorsTomas Ganz
JournalCell metabolism (Cell Metab) Vol. 7 Issue 4 Pg. 288-90 (Apr 2008) ISSN: 1550-4131 [Print] United States
PMID18396134 (Publication Type: Journal Article, Review)
Chemical References
  • Antimicrobial Cationic Peptides
  • HAMP protein, human
  • HFE protein, human
  • Hemochromatosis Protein
  • Hepcidins
  • Histocompatibility Antigens Class I
  • Membrane Proteins
  • Receptors, Transferrin
  • Iron
Topics
  • Animals
  • Antimicrobial Cationic Peptides (metabolism)
  • Hemochromatosis (genetics, metabolism)
  • Hemochromatosis Protein
  • Hepatocytes (metabolism)
  • Hepcidins
  • Histocompatibility Antigens Class I (metabolism)
  • Homeostasis
  • Humans
  • Iron (metabolism)
  • Membrane Proteins (metabolism)
  • Receptors, Transferrin (metabolism)

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