Abstract | OBJECTIVE: To report a pregnancy in a hermaphrodite and review of the literature. DESIGN: Case report and literature review. SETTING: Clinical. PATIENT(S): A patient with male-predominant mosaic karyotype 96% 46XY. INTERVENTION(S): MAIN OUTCOME MEASURE(S): RESULT(S): The current patient had previous pregnancy and a wedge biopsy of her left gonad, which demonstrated an ovotestis and an area suspicious for a gonadoblastoma. After delivery of her second pregnancy, the patient underwent a hysterectomy and bilateral salpingo-oophorectomy. The histopathologic evaluation following bilateral oophorectomy demonstrated a residual ovotestis without further evidence of a gonadoblastoma. Review of the literature identified 10 other cases of pregnancy in a hermaphrodite patient. CONCLUSION(S): This is the 11th reported case of fertility in a true hermaphrodite and only the second report of a mosaic true hermaphrodite to demonstrate fertility. This is the only case of a pregnancy involving a male-predominant mosaic 96% 46XY and the only case to confirm the genetics of the offspring.
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Authors | Samantha A Schoenhaus, Scott E Lentz, Peter Saber, Malcom G Munro, Seth Kivnick |
Journal | Fertility and sterility
(Fertil Steril)
Vol. 90
Issue 5
Pg. 2016.e7-10
(Nov 2008)
ISSN: 1556-5653 [Electronic] United States |
PMID | 18394621
(Publication Type: Case Reports, Journal Article, Review)
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Topics |
- Adult
- Female
- Fertility
- Gonadal Dysgenesis, Mixed
(genetics, pathology, physiopathology)
- Gonadoblastoma
(genetics, pathology, prevention & control)
- Humans
- Hysterectomy
- Karyotyping
- Laparoscopy
- Live Birth
- Male
- Mosaicism
- Ovarian Neoplasms
(genetics, pathology, prevention & control)
- Ovariectomy
- Ovary
(pathology, surgery)
- Ovotesticular Disorders of Sex Development
(genetics, pathology, physiopathology)
- Pregnancy
- Testicular Neoplasms
(genetics, pathology, prevention & control)
- Testis
(pathology, surgery)
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