RanBP2: a tumor suppressor with a new twist on TopoII, SUMO, and centromeres.

Abstract

In vertebrate cells, the small ubiquitin-like modifier SUMO plays a poorly defined role in targeting DNA topoisomerase II (TopoII) to centromeres (CENs) during mitosis, presumably to facilitate the untangling of sister chromatids as cells transition into anaphase. A new study by Dawlaty in the April 4 issue of Cell identifies the nucleoporin RanBP2 as a novel tumor suppressor that acts as a SUMO ligase for TopoII. Analysis of this interaction reveals TopoII recruitment to CENs is likely to play an important role in preventing chromosome segregation errors that lead to cancer.

• Authors: Michelle S Navarro, Jeff Bachant
• Journal: Cancer cell (Cancer Cell) Vol. 13 Issue 4 Pg. 293-5 (Apr 2008) ISSN: 1878-3686 [Electronic] United States
• PMID: 18394551 (Publication Type: Journal Article)

Chemical References

• Molecular Chaperones
• Nuclear Pore Complex Proteins
• Small Ubiquitin-Related Modifier Proteins
• Tumor Suppressor Proteins
• ran-binding protein 2
• DNA Topoisomerases, Type II

Topics

• Animals
• Centromere (metabolism)
• Chromosome Aberrations
• DNA Topoisomerases, Type II (metabolism)
• Mice
• Molecular Chaperones (metabolism)
• Nuclear Pore Complex Proteins (metabolism)
• Protein Binding
• Small Ubiquitin-Related Modifier Proteins (metabolism)
• Tumor Suppressor Proteins (metabolism)
• Xenopus