Abstract | RATIONALE: Selective cognitive impairments, including those of executive function as assessed using the Wisconsin Card Sort Test or intradimensional-extradimensional (ID-ED) tests, are a key feature of schizophrenia but remain inadequately treated by existing therapies. Recently, however, modafinil has been shown to improve attentional set-shifting performance in patients with schizophrenia. OBJECTIVE: The present study evaluated the recently described analogous rat ID-ED attentional set-shifting task by investigating the effects of various pharmacological challenges to a phencyclidine (PCP)-induced ED shift impairment, namely, haloperidol, risperidone, sertindole, and modafinil. MATERIALS AND METHODS: Rats were subjected to a subchronic systemic administration of either saline vehicle or PCP (5 mg/kg i.p. b.i.d. for 7 days) followed by a 7-day washout period. During this period, rats were trained to dig in baited bowls for a food reward and to discriminate based on odor or digging media. In a single test session conducted the day after the washout period (day 8), rats performed a series of discriminations following acute administration of either vehicle, or haloperidol (0.1 mg/kg s.c.), or risperidone (0.2 mg/kg i.p.), or sertindole (1.25 mg/kg p.o.) or modafinil (64 mg/kg p.o.). RESULTS: CONCLUSIONS: Overall, these findings further support that the rat ID-ED test in subchronic PCP-treated rats has utility and validity as a preclinical model of the cognitive symptoms of schizophrenia and demonstrates back-translational potential.
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Authors | Pascal Goetghebeur, Rebecca Dias |
Journal | Psychopharmacology
(Psychopharmacology (Berl))
Vol. 202
Issue 1-3
Pg. 287-93
(Jan 2009)
ISSN: 1432-2072 [Electronic] Germany |
PMID | 18392753
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Antipsychotic Agents
- Benzhydryl Compounds
- Central Nervous System Stimulants
- Excitatory Amino Acid Antagonists
- Imidazoles
- Indoles
- sertindole
- Phencyclidine
- Haloperidol
- Risperidone
- Modafinil
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Topics |
- Animals
- Antipsychotic Agents
(pharmacology)
- Attention
(drug effects)
- Benzhydryl Compounds
(pharmacology)
- Central Nervous System Stimulants
(pharmacology)
- Cognition Disorders
(chemically induced, drug therapy, psychology)
- Conditioning, Operant
(drug effects)
- Discrimination, Psychological
(drug effects)
- Excitatory Amino Acid Antagonists
- Haloperidol
(pharmacology)
- Imidazoles
(pharmacology)
- Indoles
(pharmacology)
- Male
- Modafinil
- Phencyclidine
- Psychomotor Performance
(drug effects)
- Rats
- Risperidone
(pharmacology)
- Schizophrenic Psychology
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