Systematic analysis of the salutary effect of estrogen on cardiac performance after trauma-hemorrhage.

Abstract

Although 17beta-estradiol (estrogen) and estrogen receptor (ER) agonist administration after trauma-hemorrhage improves cardiac function, it remains unknown what the optimal estrogen or ER agonist dosage is to elicit this beneficial effect. To study this, the dose-dependent effects of estrogen, propylpyrazole triol (ER-alpha agonist), and diarylpropionitrile (DPN; ER-beta agonist) on heart performance (+dP/dt) were determined in sham rats and in experimental animals at the time of maximal bleedout (MBO) or at 2 h after trauma-hemorrhage. The results showed that estrogen and DPN induced dose-dependent increases in the maximal rate of left ventricular pressure increase (+dP/dt) in all groups, whereas propylpyrazole triol was ineffective at all doses. The maximal dose and the 50% effective dose of DPN were approximately 100-fold lower than those of estrogen. The half-life of estrogen in plasma was approximately 25 min in sham and MBO groups. A positive correlation between the estrogen-induced increase in +dP/dt and survival in MBO rats were observed. These results collectively suggest that the salutary effects of estrogen on cardiac performance are dose-dependent and mediated via ER-beta.

• Authors: Zheng F Ba, Jun-Te Hsu, Jianguo Chen, Wen-Hong Kan, Martin G Schwacha, Irshad H Chaudry
• Journal: Shock (Augusta, Ga.) (Shock) Vol. 30 Issue 5 Pg. 585-9 (Nov 2008) ISSN: 1540-0514 [Electronic] United States
• PMID: 18391854 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• 2,3-bis(4-hydroxyphenyl)-propionitrile
• Estrogen Receptor beta
• Estrogens
• Nitriles
• Phenols
• Propionates
• Pyrazoles
• 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol
• Estradiol

Topics

• Animals
• Estradiol (pharmacology)
• Estrogen Receptor beta (agonists)
• Estrogens (pharmacology)
• Heart (drug effects, physiopathology)
• Hemorrhage (physiopathology)
• Male
• Nitriles (pharmacology)
• Phenols
• Propionates (pharmacology)
• Pyrazoles (pharmacology)
• Rats
• Rats, Sprague-Dawley