The effect of meperidine-impregnated autogenous free fat grafts on postoperative pain management in lumbar disc surgery.

Abstract

STUDY DESIGN:

Prospective, randomized, double-blind clinical study.

OBJECTIVE:

To examine the effect of meperidine-impregnated autogenous free fat grafts (AFFGs) on postoperative pain management after 1-level, first-time lumbar disc surgery.

SUMMARY OF BACKGROUND DATA:

Uncontrolled postoperative pain impedes patient recovery. Insufficient control of postoperative pain makes it difficult to convince new patients to undergo the lumbar disc surgery.

METHODS:

Twenty-seven patients scheduled to undergo lumbar microdiscectomy for the first time were divided into 2 groups by a randomized double-blind method. Group 1 patients received a meperidine-impregnated AFFG in the epidural area. Group 2 received the graft without meperidine impregnation. Both groups were asked to use a Patient Controlled Analgesia device to deliver tramadol, and at 1, 4, 12, and 24 hours postoperatively, the amounts of tramadol used and pain severity on the 10-cm Visual Analog Scale (VAS) were recorded.

RESULTS:

The VAS scores and total tramadol use were both lower in group 1 compared with the control group (P<0.05). The first hour of VAS scores were significantly lower in group 1 than in the control group (P<0.05).

CONCLUSIONS:

In this study, we helped patients, who underwent 1-level, first-time lumbar microdiscectomy have a postoperative pain-free and comfortable period by using epidural meperidine-impregnated AFFGs.

• Authors: Erdal Kalkan, Fuat Torun, Aybars Tavlan, Sahika Liva Cengiz, Bülent Kaya
• Journal: Journal of spinal disorders & techniques (J Spinal Disord Tech) Vol. 21 Issue 2 Pg. 92-5 (Apr 2008) ISSN: 1536-0652 [Print] United States
• PMID: 18391711 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Analgesics, Opioid
• Tramadol
• Meperidine

Topics

• Adipose Tissue (transplantation)
• Adult
• Analgesia, Epidural
• Analgesia, Patient-Controlled
• Analgesics, Opioid (administration & dosage)
• Female
• Humans
• Intervertebral Disc Displacement (surgery)
• Lumbar Vertebrae (surgery)
• Male
• Meperidine (administration & dosage)
• Middle Aged
• Pain, Postoperative (drug therapy)
• Spinal Fusion
• Tramadol (administration & dosage)
• Transplantation, Autologous
• Treatment Outcome