Abstract | UNLABELLED: MATERIALS AND METHODS: we used main left bronchial rings mounted in wire myograph to assess the effects of Ang II and theophylline on airway smooth muscle. RESULTS: On both normal and OVA sensitized rats theophylline did not significantly modify either Ang II contractile effects or Ang II amplification of acetylcholine (ACh)-induced bronchoconstriction. On the other hand, on sensitized rat after antigen challenge, theophylline pretreatment reduced Ang II inhibition of terbutaline--induced relaxation of bronchial rings precontracted with ACh, increasing both EC50 and E(max) of terbutaline effects with 22.04 +/- 3.48% and 19.48 +/- 1.67%, respectively. CONCLUSION: These findings suggested that, in addition to bronchodilatory and antiinflammatory actions, theophylline could block some effects of intrapulmonary RAS activated in pathologically states as antigen sensitization and challenge.
|
Authors | Irina Luciana Dumitriu, B C Petrescu, Beatrice Mihaela Gurzu, B Gurzu, M Costuleanu, Simona Mihaela Slătineanu |
Journal | Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi
(Rev Med Chir Soc Med Nat Iasi)
2007 Oct-Dec
Vol. 111
Issue 4
Pg. 986-9
ISSN: 0048-7848 [Print] Romania |
Vernacular Title | Interacţiunea angiotensină II--teofilină pe inele de bronhie de sobolan. |
PMID | 18389792
(Publication Type: English Abstract, Journal Article)
|
Chemical References |
- Bronchodilator Agents
- Vasoconstrictor Agents
- Angiotensin II
- Ovalbumin
- Theophylline
- Terbutaline
|
Topics |
- Angiotensin II
(pharmacology)
- Animals
- Bronchi
(drug effects)
- Bronchoconstriction
(drug effects)
- Bronchodilator Agents
(pharmacology)
- Disease Models, Animal
- Dose-Response Relationship, Drug
- In Vitro Techniques
- Muscle, Smooth
(drug effects)
- Ovalbumin
(adverse effects)
- Rats
- Rats, Wistar
- Renin-Angiotensin System
(drug effects)
- Terbutaline
(pharmacology)
- Theophylline
(pharmacology)
- Vasoconstrictor Agents
(pharmacology)
|