Cytotoxic-antineoplastic derivatives of prenyl-1,2-naphthohydroquinone.

Abstract

Several new prenyl-1,2-naphthohydroquinone derivatives have been prepared by chemical modifications of Diels-Alder products which were obtained from cycloaddition of alpha-myrcene to 1,2-benzoquinone and then evaluated in vitro for their cytotoxic activity against A-549 lung carcinoma, HT-29 colon carcinoma, and MB-231 breast adeno-carcinoma culture cells. Most of them exhibited GI50 values in the microM-concentration level.

• Authors: Aurora Molinari, Alfonso Oliva, Claudia Ojeda, José M Miguel del Corral, M Angeles Castro, Carmen Cuevas, Arturo San Feliciano
• Journal: Archiv der Pharmazie (Arch Pharm (Weinheim)) Vol. 341 Issue 5 Pg. 301-6 (May 2008) ISSN: 0365-6233 [Print] Germany
• PMID: 18389518 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Hydroquinones

Topics

• Antineoplastic Agents (chemical synthesis, pharmacology)
• Cell Line, Tumor
• Humans
• Hydroquinones (chemical synthesis, pharmacology)
• Structure-Activity Relationship