Abstract | PURPOSE OF REVIEW: RECENT FINDINGS:
TNF-alpha has been implicated in the pathogenesis of heart failure. It has direct deleterious effects on the myocardium in the setting of acute injury or chronic heart failure. In animal models, TNF-alpha is important in cardiac remodeling, leading to cardiac dysfunction following acute injury. Both incident and worsening heart failure have been reported in patients with rheumatoid arthritis who are treated with anti- TNF-alpha therapy. Recent cohort studies, however, have shown no increased risk and, in some, a protective effect on the risk of heart failure. Certain traditional cardiovascular risk factors have a relatively lesser contribution to cardiovascular morbidity and mortality in patients with rheumatoid arthritis, suggesting that disease-related perturbations of the cytokine network may contribute to the excess risk of heart failure in these patients. SUMMARY:
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Authors | Maria I Danila, Nivedita M Patkar, Jeffrey R Curtis, Kenneth G Saag, Gim Gee Teng |
Journal | Current opinion in rheumatology
(Curr Opin Rheumatol)
Vol. 20
Issue 3
Pg. 327-33
(May 2008)
ISSN: 1040-8711 [Print] United States |
PMID | 18388526
(Publication Type: Journal Article, Review)
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Chemical References |
- Antirheumatic Agents
- Immunologic Factors
- Tumor Necrosis Factor-alpha
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Topics |
- Antirheumatic Agents
(adverse effects)
- Arthritis, Rheumatoid
(complications, drug therapy)
- Clinical Trials as Topic
- Cohort Studies
- Contraindications
- Heart Failure
(etiology)
- Humans
- Immunologic Factors
(adverse effects)
- Risk Factors
- Tumor Necrosis Factor-alpha
(antagonists & inhibitors, physiology)
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