SRC-3 transcription-coupled activation, degradation, and the ubiquitin clock: is there enough coactivator to go around in cells?

Abstract

Overexpression of nuclear receptor coactivators is a frequent event in breast cancer cells and is recognized as a key mechanism for these cells to maximize their oncogenic growth state. Steroid receptor coactivator-3 [(SRC-3), also known as amplified in breast cancer-1 or AIB1] is foremost among these overexpressed oncogenic coactivators, being overexpressed in most breast cancers. Because of its oncogenic potential, normal cells must carefully control its cellular concentration. We discuss how SRC-3 quantitatively influences estrogen-regulated gene transcription when it is at limiting concentrations in normal breast cells and at nonlimiting concentrations in breast cancer cells. Precise control of the cellular concentration of SRC-3 may thus serve as a mechanism for defining growth responses to estrogen receptors and other growth-promoting transcription factors.

• Authors: David M Lonard, Bert W O'Malley
• Journal: Science signaling (Sci Signal) Vol. 1 Issue 13 Pg. pe16 (Apr 01 2008) ISSN: 1937-9145 [Electronic] United States
• PMID: 18385039 (Publication Type: Journal Article)

Chemical References

• Trans-Activators
• Ubiquitin
• Histone Acetyltransferases
• NCOA3 protein, human
• Nuclear Receptor Coactivator 3

Topics

• Cell Line, Tumor
• Histone Acetyltransferases (physiology)
• Humans
• Nuclear Receptor Coactivator 3
• Trans-Activators (physiology)
• Transcriptional Activation
• Ubiquitin (physiology)