Integrin scintimammography using a dedicated breast imaging, solid-state gamma-camera and (99m)Tc-labelled NC100692.

Abstract

OBJECTIVE:

Integrin scintimammography with NC100692 and a dedicated gamma-camera, LumaGEM, based on semi-conductor technology, was performed to investigate the detection ability of this combination in breast cancer.

METHODS:

Eight patients with a high suspicion of breast cancer were administered 600-750 MBq (99m)Tc-labelled NC100629. Two acquisitions using a cranio-caudal and a lateral view were used, with moderate compression of the breast.

RESULTS:

LumaGEM scintigraphy revealed 9 of 11 malignancies, sized 6-20 mm. Two lesions in patients with multicentric disease were not diagnosed, one of which measured only 2.5 mm. In one patient, the procedure was inconclusive, due to major breast hypertrophy.

CONCLUSION:

The combined use of NC100629 and a dedicated gamma-camera for breast imaging was highly effective in diagnosing breast cancer.

• Authors: Tore Bach-Gansmo, Trond V Bogsrud, Arne Skretting
• Journal: Clinical physiology and functional imaging (Clin Physiol Funct Imaging) Vol. 28 Issue 4 Pg. 235-9 (Jul 2008) ISSN: 1475-0961 [Print] England
• PMID: 18384623 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Integrin alphaVbeta3
• Organotechnetium Compounds
• Peptides, Cyclic
• technetium 99m NC 100692

Topics

• Aged
• Breast (diagnostic imaging)
• Breast Neoplasms (diagnostic imaging)
• Female
• Gamma Cameras
• Humans
• Integrin alphaVbeta3 (metabolism)
• Mammography
• Middle Aged
• Neovascularization, Pathologic (diagnostic imaging)
• Organotechnetium Compounds (metabolism)
• Peptides, Cyclic (metabolism)
• Radionuclide Imaging