Abstract | BACKGROUND: This study investigated a novel approach for tumor ablation therapy using an alternating magnetic field combined with a sintered MgFe2O4 needle. This method differs from radiofrequency ablation (RFA) by dielectric heating with regard to the heating mechanism and improves some weak points of these conventional thermotherapies. MATERIALS AND METHODS: Nude mice mimicking human breast cancer BT474 were treated using this method. The extent of tumor death was assessed after ablation. RESULTS: CONCLUSION: This novel ablation therapy appeared to be more effective and less invasive for treatment of breast cancer treatment than RFA.
|
Authors | Shungo Yukumi, Yuji Watanabe, Atsushi Horiuchi, Takashi Doi, Kohichi Sato, Motohira Yoshida, Tsunehiro Maehara, Hiromichi Aono, Takashi Naohara, Kanji Kawachi |
Journal | Anticancer research
(Anticancer Res)
2008 Jan-Feb
Vol. 28
Issue 1A
Pg. 69-74
ISSN: 0250-7005 [Print] Greece |
PMID | 18383826
(Publication Type: Journal Article)
|
Chemical References |
- Ferric Compounds
- ferric oxide
- Magnesium Oxide
- Dihydrolipoamide Dehydrogenase
|
Topics |
- Animals
- Breast Neoplasms
(surgery)
- Catheter Ablation
(instrumentation, methods)
- Cell Line, Tumor
- Dihydrolipoamide Dehydrogenase
(metabolism)
- Disease Models, Animal
- Female
- Ferric Compounds
- Humans
- Hyperthermia, Induced
(instrumentation, methods)
- Magnesium Oxide
- Mice
- Mice, Nude
- Needles
- Xenograft Model Antitumor Assays
|