Abstract | PURPOSE OF REVIEW: The promise of pharmacogenomics is that it will one day result in targeted heart failure therapy that maximizes individual benefit and diminishes risk. Recent reports from the Beta Blocker Evaluation Survival and African American Heart Failure clinical trials provide a roadmap of how this promise may soon be realized. This review will discuss recent investigations of pharmacogenomics in heart failure, and the challenge of converting genomic heterogeneity into a usable clinical tool. RECENT FINDINGS: SUMMARY: Modern clinical trials will increasingly have a pharmacogenetic component to allow more efficient targeting of therapeutics. Investigators are beginning to delineate the genomic basis for differences in drug efficacy between black and white heart failure cohorts. Pharmacogenomics will have an increasing role in the treatment of heart failure patients.
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Authors | Dennis M McNamara |
Journal | Current opinion in cardiology
(Curr Opin Cardiol)
Vol. 23
Issue 3
Pg. 261-8
(May 2008)
ISSN: 0268-4705 [Print] United States |
PMID | 18382216
(Publication Type: Journal Article, Review)
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Topics |
- Black or African American
- Genetic Heterogeneity
- Genotype
- Heart Failure
(drug therapy, ethnology, genetics)
- Humans
- Pharmacogenetics
- Polymorphism, Genetic
- Randomized Controlled Trials as Topic
- White People
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