Difficulties in diagnosis and management of ectopic Cushing syndrome.

Abstract

A 18-year-old man presented to a local hospital with muscle weakness, facial edema, and a 6 kg weight gain over 2 months. After a complete work-up, he was diagnosed with pituitary Cushing syndrome and treated with a bilateral adrenalectomy for Cushing syndrome and pituitary radiotherapy for Nelson syndrome. Twenty-five years later, his ectopic source of adrenocorticotropic hormone was revealed as a pulmonary neuroendocrine tumor, and a pulmonary resection was performed. Subsequently, a biochemical and clinical remission including hyperpigmentation was achieved.

• Authors: Sukki Cho, Yong Joon Ra, Choon-Taek Lee, Jin-Haeng Chung, Sook-Whan Sung, Sanghoon Jheon
• Journal: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer (J Thorac Oncol) Vol. 3 Issue 4 Pg. 444-6 (Apr 2008) ISSN: 1556-1380 [Electronic] United States
• PMID: 18379368 (Publication Type: Case Reports, Journal Article)

Chemical References

• Adrenocorticotropic Hormone

Topics

• ACTH Syndrome, Ectopic (diagnosis, radiotherapy, surgery)
• Adolescent
• Adrenalectomy
• Adrenocorticotropic Hormone (metabolism)
• Cushing Syndrome (diagnosis, radiotherapy, surgery)
• Humans
• Lung Neoplasms (diagnosis, etiology, surgery)
• Male
• Nelson Syndrome (diagnosis, radiotherapy, surgery)
• Neuroendocrine Tumors (diagnosis, etiology, surgery)
• Positron-Emission Tomography