Inhibitory constituents of aldose reductase in the fruiting body of Phellinus linteus.

Abstract

In an effort to characterize active principles for diabetic complication from medicinal mushroom, aldose reductase inhibitors were isolated from the fruiting body of Phellinus linteus and identified as hispidin (5), phelligridimer A (6), davallialactone (7), methyldavallialactone (8), hypholomine B (9), interfungins A (10), and inoscavin A (11), together with protocatechuic acid (1), protocatechualdehyde (2), caffeic acid (3), and ellagic acid (4). Their structures were elucidated by spectroscopic analyses. Among them, davallialactone (7), hypholomine B (9), and ellagic acid (4) exhibited potent rat lens aldose reductase and human recombinant aldose reductase inhibitory activity with IC50 values of 0.33, 0.82, 0.63 microM and 0.56, 1.28, 1.37 microM, respectively.

• Authors: Yeon Sil Lee, Young-Hee Kang, Ju-Young Jung, Il-Jun Kang, Sang-No Han, Jong-Sang Chung, Hyun-Kyung Shin, Soon Sung Lim
• Journal: Biological & pharmaceutical bulletin (Biol Pharm Bull) Vol. 31 Issue 4 Pg. 765-8 (Apr 2008) ISSN: 0918-6158 [Print] Japan
• PMID: 18379080 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Enzyme Inhibitors
• Indicators and Reagents
• Recombinant Proteins
• Aldehyde Reductase

Topics

• Aldehyde Reductase (antagonists & inhibitors)
• Animals
• Basidiomycota (chemistry)
• Enzyme Inhibitors (isolation & purification, pharmacology)
• Freeze Drying
• Fruiting Bodies, Fungal (chemistry)
• Humans
• Indicators and Reagents
• Lens, Crystalline (enzymology)
• Magnetic Resonance Spectroscopy
• Rats
• Rats, Sprague-Dawley
• Recombinant Proteins (chemistry)