Abstract |
The objective of this study was to determine the impact of glucocorticoid exposure on lumbar spine bone mineral density (BMD) in children while concurrently measuring their calcium intake, serum 25-OH vitamin D levels, and physical activity. Forty-three patients (4-18 years) with renal glomerular diseases, dermatomyositis, inflammatory bowel disease, juvenile rheumatoid arthritis, post-solid organ transplant, and Duchenne muscular dystrophy were studied. All received at least 5 mg per day of prednisone for more than 6 months. The mean BMD z score was 0 +/- 0.2 (range, -3.8 to +3.3) with 2 patients (5%) having z scores less than -2. The mean daily calcium intake was 1147 +/- 145 g, with 1 patient having hypovitaminosis D (<15 ng/mL). The mean physical activity level was 7.8 +/- 0.8 h/wk. The small reductions in BMD observed in our population suggest that screening is likely not warranted in all children with chronic glucocorticoid exposure.
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Authors | Valeria C Cohran, Mark Griffiths, James E Heubi |
Journal | Clinical pediatrics
(Clin Pediatr (Phila))
Vol. 47
Issue 5
Pg. 469-75
(Jun 2008)
ISSN: 0009-9228 [Print] United States |
PMID | 18378941
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Calcium, Dietary
- Glucocorticoids
- Vitamin D
- Prednisone
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Topics |
- Adolescent
- Arthritis, Juvenile
(drug therapy)
- Bone Density
- Calcium, Dietary
(administration & dosage)
- Child
- Child, Preschool
- Cross-Sectional Studies
- Dermatomyositis
(drug therapy)
- Female
- Glucocorticoids
(adverse effects)
- Humans
- Inflammatory Bowel Diseases
(drug therapy)
- Kidney Diseases
(drug therapy)
- Kidney Glomerulus
- Lumbar Vertebrae
- Male
- Motor Activity
- Muscular Dystrophy, Duchenne
(drug therapy)
- Osteoporosis
(chemically induced)
- Prednisone
(adverse effects)
- Transplants
- Vitamin D
(blood)
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