Greek hyperinsulinemic women, with or without polycystic ovary syndrome, display altered inositols metabolism.

Abstract

UNLABELLED:

BACKGROUND We have shown that American women with polycystic ovary syndrome (PCOS) have decreased glucose-stimulated release of a putative mediator of insulin action, D-chiro-inositol (DCI)-containing inositolphosphoglycan (DCI-IPG), and increased urinary clearance of DCI (uCl(DCI)), which was associated with hyperinsulinemia.

METHODS:

DCI levels and the release of insulin and DCI-IPG during an oral glucose tolerance test (AUCs) were assessed in 27 Greek PCOS and 10 normal Greek women.

RESULTS:

PCOS women were heavier than controls (BMI = 28.4 versus 23.7 kg/m(2), P = 0.05) with higher waist-to-hip ratios (WHR = 0.78 versus 0.71, P = 0.009) and increased free testosterone (P = 0.048) and AUC(insulin) (P = 0.04). In PCOS women, incremental AUC(DCI-IPG) was significantly decreased by 59% (2158 versus 5276%.min, P = 0.01), even after correction for BMI and WHR. Finally, increased uCl(DCI) (r = 0.35, P = 0.04) and decreased AUC(DCI-IPG) (r = 0.46, P = 0.004) were significantly associated with hyperinsulinemia in all women together, even after correction for BMI and WHR (Ps = 0.02 and 0.007), and regardless of PCOS status.

CONCLUSIONS:

Greek women, with or without PCOS, display increased uCl(DCI) and decreased AUC(DCI-IPG) in association with higher insulin levels but independent of adiposity. Increased clearance of inositols might reduce tissue availability of DCI and decrease the release of DCI-IPG mediator, which could contribute to insulin resistance and compensatory hyperinsulinemia in Greek women, as previously described in American women.

• Authors: Jean-Patrice Baillargeon, John E Nestler, Richard E Ostlund, Teimuraz Apridonidze, Evanthia Diamanti-Kandarakis
• Journal: Human reproduction (Oxford, England) (Hum Reprod) Vol. 23 Issue 6 Pg. 1439-46 (Jun 2008) ISSN: 1460-2350 [Electronic] England
• PMID: 18375940 (Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Insulin
• Inositol

Topics

• Adolescent
• Adult
• Body Mass Index
• Case-Control Studies
• Female
• Glucose Tolerance Test
• Greece
• Humans
• Hyperinsulinism (blood, complications)
• Inositol (blood, urine)
• Insulin (blood)
• Polycystic Ovary Syndrome (complications, metabolism)