A remote controlled system for the preparation of 7 alpha-[18F]fluoro-17 alpha-methyl 5 alpha-dihydrotestosterone ([18F]FMDHT) using microwave.

Abstract

For non-invasive imaging of the prostate cancer, we synthesized 7 alpha-fluoro-17 alpha-methyl 5 alpha-dihydrotestosterone ([(18)F]FMDHT) for androgen receptor mediated PET imaging. Preliminary in vitro and in vivo evaluations of this compound show promise. We designed and implemented a remote controlled system for reliable, efficient, and safe handling of radioactivity during the radiochemical synthesis of [(18)F]FMDHT. The key features of this report are the microwave assisted radiochemical synthesis, increased radiochemical yields, improved radiochemical purity, reduced overall synthesis time, and remote controlled automation of the entire synthesis. The overall synthesis using microwave reaction took 60-70 min and provided the desired product in 20-30% radiochemical yields with >99% radiochemical purity.

• Authors: Sudha Garg, Andrew J H Lynch, Aniruddha K Doke, Richard C Minton, Pradeep K Garg
• Journal: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine (Appl Radiat Isot) Vol. 66 Issue 5 Pg. 612-8 (May 2008) ISSN: 0969-8043 [Print] England
• PMID: 18372185 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• 18F-MDHT
• Dihydrotestosterone

Topics

• Chromatography, High Pressure Liquid
• Dihydrotestosterone (analogs & derivatives, chemical synthesis)
• Microwaves
• Quality Control
• Spectrophotometry, Ultraviolet