Decreased levels of GABA in the inferior colliculus of the epilepsy-prone hamster (GPG/Vall).

Abstract	Abnormalities in GABA levels in the central nucleus of the inferior colliculus (CNIC) of the epilepsy-prone hamster (GPG/Vall) were evaluated by using immunohistochemistry, densitometry and high performance liquid chromatography (HPLC). These findings demonstrate a decrease both in GABA immunostaining (neuropil and neurons) and in GABA concentration (HPLC) in the CNIC of the epileptic hamster compared to control animals. These decreases may reflect a reduced availability of this neurotransmitter that may act as an audiogenic seizure-initiating factor.
Authors	Verónica Fuentes-Santamaría, Juan Carlos Alvarado, Antonio S Herranz, Natividad García-Atarés, Dolores E López
Journal	Epilepsy research (Epilepsy Res) Vol. 79 Issue 2-3 Pg. 224-7 (May 2008) ISSN: 0920-1211 [Print] Netherlands
PMID	18372163 (Publication Type: Journal Article)
Chemical References	gamma-Aminobutyric Acid
Topics	Animals Chromatography, High Pressure Liquid Cricetinae Densitometry Epilepsy (genetics, metabolism) Image Processing, Computer-Assisted Immunohistochemistry Inferior Colliculi (metabolism) Mesocricetus gamma-Aminobutyric Acid (metabolism)

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