Abstract | OBJECTIVES: METHODS: Serum HA, YKL-40, and FS-II were retrospectively assessed and correlated with Ishak stages and DQF scores in 75 patients with chronic hepatitis C (HCV). Spearman's rho statistics assessed relationships among all parameters, and receiver operator characteristic curves evaluated accuracy of each parameter when compared to the Ishak stages. RESULTS: All three serum markers and DQF correlated highly with one another (P < or = 0.01) and with Ishak stages of fibrosis. Among the serum markers, HA was effective in discriminating between Ishak stages 0-1 and Ishak stages 2-3 compared with FS-II, with an area under the curve of 0.76 versus 0.66 and a false-positive rate of 0.33 versus 0.67, respectively. All three serum markers predicted advanced fibrosis and cirrhosis. YKL-40 had the highest false-positive rates in all categories of fibrosis. CONCLUSIONS: HA can be utilized as a reliable surrogate marker in distinguishing three clinically relevant stages of fibrosis: absent/minimal, intermediate, and advanced/ cirrhosis. HA should be considered as a cost-effective alternative to other serum markers for staging fibrosis and for determining the timing and selection of HCV treatment.
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Authors | Preeti Mehta, Robert Ploutz-Snyder, Jyotirmoy Nandi, Sekou R Rawlins, Schuyler O Sanderson, Robert A Levine |
Journal | The American journal of gastroenterology
(Am J Gastroenterol)
Vol. 103
Issue 4
Pg. 928-36
(Apr 2008)
ISSN: 1572-0241 [Electronic] United States |
PMID | 18371145
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adipokines
- Biomarkers
- CHI3L1 protein, human
- Chitinase-3-Like Protein 1
- Extracellular Matrix Proteins
- Glycoproteins
- Lectins
- Hyaluronic Acid
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Topics |
- Adipokines
- Adult
- Aged
- Biomarkers
(blood)
- Biopsy
- Chitinase-3-Like Protein 1
- Extracellular Matrix Proteins
(blood)
- Female
- Glycoproteins
(blood)
- Hepatitis C, Chronic
(blood, pathology)
- Humans
- Hyaluronic Acid
(blood)
- Lectins
- Liver Cirrhosis
(blood)
- Male
- Middle Aged
- ROC Curve
- Retrospective Studies
- Sensitivity and Specificity
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