[Non-pharmacological diabetes therapy].

Abstract

Diabetes mellitus type 2 is a life-style disease that is triggered by obesity and lack of physical activity. The pathophysiological basis of the disease is a reduction of insulin sensitivity, that is caused by the trigger factors. Glucose metabolic disorders appear if overproduction of insulin can not compensate the insulin resistance. In early phases postprandial blood glucose is increased, in late phases elevation of fasting blood glucose is noted. In the general awareness manifestation of type 2 diabetes is associated with an initiation of a pharmacological therapy. This is not the case, as described in detail in this review. Next to epidemiological studies, which indicate trigger factors, intervention trials will be discussed that led to a shift in paradigm in the diabetology. Non-pharmacological interventions are a therapeutical alternative in a lot of patients or are able to reduce the amount of antidiabetic agents significantly.

• Authors: Stephan Martin, Hubert Kolb
• Journal: Medizinische Monatsschrift fur Pharmazeuten (Med Monatsschr Pharm) Vol. 31 Issue 2 Pg. 42-51 (Feb 2008) ISSN: 0342-9601 [Print] Germany
• Vernacular Title: Nichtpharmakologische Diabetestherapie.
• PMID: 18368977 (Publication Type: English Abstract, Journal Article, Review)

Topics

• Diabetes Mellitus, Type 2 (epidemiology, prevention & control, therapy)
• Exercise (physiology)
• Humans
• Life Style
• Physical Fitness
• Risk Factors