Abstract |
Laron syndrome (LS, congenital primary GH insensitivity) is caused by deletions or mutations in the GH receptor gene, resulting in an inability to generate insulin-like growth factor-I ( IGF-I). If untreated, the deficiency of IGF-I results in severe dwarfism, as well as skeletal and muscular underdevelopment. The only treatment is the daily administration of recombinant IGF-I. This review summarizes the present experience by several groups worldwide. The main conclusions are: A. The one or two injections regimen result in the same growth velocity; B. The growth velocity obtained with IGF-I administration is smaller than that observed with hGH in children with congenital isolated GH deficiency; C. Overdosage of IGF-I causes a series of adverse effects which can be avoided by carefully monitoring the serum IGF-I and GH levels.
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Authors | Zvi Laron |
Journal | Pediatric endocrinology reviews : PER
(Pediatr Endocrinol Rev)
Vol. 5
Issue 3
Pg. 766-71
(Mar 2008)
ISSN: 1565-4753 [Print] Israel |
PMID | 18367997
(Publication Type: Journal Article, Review)
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Chemical References |
- Insulin-Like Growth Factor I
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Topics |
- Child
- Humans
- Insulin-Like Growth Factor I
(therapeutic use)
- Laron Syndrome
(drug therapy)
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