Effect of hemocoagulase for prevention of pulmonary hemorrhage in critical newborns on mechanical ventilation: a randomized controlled trial.

Abstract

OBJECTIVE:

To investigate the role of hemocoagulase to prevent pulmonary hemorrhage in critical newborns on mechanical ventilation.

DESIGN:

Randomized controlled trial.

SETTING:

Neonatal Intensive Care Unit of an affiliated hospital of a Medical University.

CHILDREN:

Seventy-two critical newborn infants on mechanical ventilation.

INTERVENTION:

The involved neonates were divided randomly into two groups. Forty-one patients were treated with prophylactic hemocoagulase(dripped through the endotracheal tube), and other 31 neonates served as controls.

OUTCOME MEASURES:

Incidence of pulmonary hemorrhage, time of ceasing pulmonary hemorrhage if occurred, time of withdrawing of mechanical ventilation in the survivors, and mortality.

RESULTS:

The incidence of pulmonary hemorrhage (12% vs 42%) and the time of ceasing pulmonary hemorrhage (1.36 +/- 0.65 vs 3.58 +/- 0.82, days), were significantly less in infants treated with prophylactic hemocoagulase as compared with the controls (P<0.05). The time to withdrawal of mechanical ventilation was less in the intervention group (3.20 +/- 0.45 vs 5.04 +/- 1.51 days) (P < 0.05). The mortality in children who received hemocoagulase was 22.0%, which was significantly less than controls (41.9 %) (P < 0.05).

CONCLUSION:

Prophylactic use of hemocoagulase in mechanically ventilated neonates is effective against pulmonary hemorrhage.

• Authors: Yuan Shi, Jinning Zhao, Shifang Tang, Feng Pan, Lei Liu, Zhaoxia Tian, Huangqiang Li
• Journal: Indian pediatrics (Indian Pediatr) Vol. 45 Issue 3 Pg. 199-202 (Mar 2008) ISSN: 0019-6061 [Print] India
• PMID: 18367764 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Hemostatics
• Batroxobin

Topics

• Apgar Score
• Batroxobin (therapeutic use)
• Case-Control Studies
• Female
• Gestational Age
• Hemorrhage (drug therapy)
• Hemostatics (therapeutic use)
• Humans
• Incidence
• Infant, Newborn
• Intensive Care Units, Neonatal
• Intensive Care, Neonatal (methods)
• Lung Diseases (drug therapy)
• Male
• Respiration, Artificial