Abstract | OBJECTIVE: To study the anti-fibrotic effects of danshensu, baicalin, astragalus and Panax notoginseng saponins (PNS) and their possible mechanisms. METHODS: RESULTS: (1) Compared with the model group, the serum levels of HA and CIV decreased significantly in all four drug-treated groups, especially in the danshensu-treated group. Astragalus and baicalin had better effects over PNS (P<0.05 or 0.01). (2) In contrast to the model group, all four drugs dramatically reduced the amount of Hyp and MDA, increased SOD activity and reduced the degrees of liver fibrosis and the expressions of TIMP-1 and TGFbeta1 in liver tissues (P<0.05 or 0.01). Danshensu had the best effect, astragalus and baicalin had similar effects which were stronger than PNS. (3) All four drugs inhibited HSCs proliferation, induced HSCs apoptosis and decreased type I, III collagen synthesis of HSC. CONCLUSIONS: The four drugs could minimize the hepatic fibrosis of rats in different degrees. Danshensu had the best effect, astragalus and baicalin had similar effects. The possible mechanisms of these effects might be related to inhibiting actions on activation and proliferation, promoting apoptosis and lowering the expression of type I and type III collagen of HSCs by down-regulating the expression of TGFbeta1; the decrease in the amount of MDA and the increase of SOD activity; and the reduction of extracellular matrix by down-regulation of TIMP-1/ MMP-1.
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Authors | Xin Li, Xiao-dong Peng, Wen-li Zhang, Li-li Dai |
Journal | Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology
(Zhonghua Gan Zang Bing Za Zhi)
Vol. 16
Issue 3
Pg. 193-7
(Mar 2008)
ISSN: 1007-3418 [Print] China |
PMID | 18364078
(Publication Type: Journal Article)
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Chemical References |
- Collagen Type III
- Drugs, Chinese Herbal
- Flavonoids
- Ginsenosides
- Plant Extracts
- baicalin
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Topics |
- Animals
- Astragalus Plant
(chemistry)
- Astragalus propinquus
- Collagen Type III
(metabolism)
- Drugs, Chinese Herbal
- Flavonoids
(pharmacology)
- Ginsenosides
(pharmacology)
- Hepatic Stellate Cells
- Liver Cirrhosis, Experimental
(drug therapy)
- Male
- Panax notoginseng
(chemistry)
- Phytotherapy
- Plant Extracts
(pharmacology)
- Rats
- Rats, Sprague-Dawley
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