Transient myeloproliferative disorder and eosinophilic pericardial effusion in a down syndrome neonate.

Abstract

Transient myeloproliferative disorder seen in neonates with Down syndrome is often thought to have a benign course. The authors describe the clinical and laboratory profile of a neonate with Down phenotype and transient myeloproliferative disorder with pericardial effusion as co-morbidity. Pericardial fluid analysis showed eosinophils. Pericardial effusion resolved with prednisolone therapy. Regression in hepatosplenomegaly with clearance of blasts was seen by third week of illness. The clinical course suggested a benign infiltration of the pericardium. Presence of eosinophils supports the differentiating capability of the blast cells in transient myeloproliferative disorders.

• Authors: Rathika D Shenoy, Kamalakshi G Bhat, Nutan Kamath, Yusuf Kumble
• Journal: Pediatric hematology and oncology (Pediatr Hematol Oncol) Vol. 25 Issue 2 Pg. 123-9 (Mar 2008) ISSN: 1521-0669 [Electronic] England
• PMID: 18363179 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents, Hormonal
• Prednisolone

Topics

• Antineoplastic Agents, Hormonal (administration & dosage)
• Down Syndrome (complications, drug therapy)
• Eosinophils
• Humans
• Infant, Newborn
• Male
• Myeloproliferative Disorders (complications, drug therapy)
• Pericardial Effusion (complications, drug therapy)
• Prednisolone (administration & dosage)