Central diabetes insipidus following digestion Solanum indicum L. concentrated solution.

Abstract

In Taiwan, Solanum indicum L. has been used in folk medicine for the treatment of inflammation, toothache, ascites, edema, and wound infection. The plant is rich in solanine, an alkaloidal glycoside. We report a 43-year-old man who developed polyuria and polydipsia after taking seven doses of concentrated solution of Solanum indicum L. over two weeks. A water deprivation test and a low serum antidiuretic hormone level helped to confirm a diagnosis of central diabetes insipidus. We suggest that excessive doses of Solanum indicum L. may cause central diabetes insipidus.

• Authors: Wen-Hung Huang, Ching-Wei Hsu, Ji-Tseng Fang
• Journal: Clinical toxicology (Philadelphia, Pa.) (Clin Toxicol (Phila)) Vol. 46 Issue 4 Pg. 293-6 (Apr 2008) ISSN: 1556-9519 [Electronic] England
• PMID: 18363121 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antidiuretic Agents
• Drugs, Chinese Herbal
• Plant Extracts
• Solanaceous Alkaloids
• Solanine
• Deamino Arginine Vasopressin

Topics

• Adult
• Antidiuretic Agents (therapeutic use)
• Deamino Arginine Vasopressin (therapeutic use)
• Diabetes Insipidus, Neurogenic (chemically induced, diagnosis, drug therapy)
• Drugs, Chinese Herbal (poisoning)
• Humans
• Male
• Plant Extracts (poisoning)
• Polyuria (chemically induced, physiopathology)
• Solanaceous Alkaloids (poisoning)
• Solanine (poisoning)
• Solanum (chemistry)
• Taiwan
• Thirst (drug effects)