HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Does brain temperature correlate with intracranial pressure?

AbstractOBJECTIVE:
A positive correlation between brain temperature and intracranial pressure (ICP) has been proposed for patients under intensive care conditions.
DESIGN AND METHODS:
Data were recorded at 5-minute intervals in patients under ICP monitoring conditions. Brain temperature: combined ICP/temperature probe (Raumedic), core temperature: indwelling urinary catheter with temperature probe (Rüsch). The correlation between brain temperature and ICP was assessed by computing an estimated mean correlation coefficient (re) and by a time series analysis.
PATIENTS:
Forty consecutive neurosurgical patients receiving intensive care therapy for trauma, cerebrovascular malformation, and spontaneous hemorrhage were studied. A total of 48,892 measurements (9778 h) were analyzed. No additional interventions were performed.
RESULTS:
The median ICP was 14 mm Hg (range: -13 to 167). The brain temperature (median 38 degrees C; range 23.2 to 42.1) was 0.3 degrees C (range: -3.6 to 2.6) higher than the core temperature (median 37.7 degrees C; range 16.6 to 42.0), P<0.001. The mean Pearson correlation between ICP and brain temperature in all patients was re=0.13 (P<0.05); the time series analysis (assuming a possible lagged correlation between ICP and brain temperature) revealed a mean correlation of 0.05+/-0.25 (P<0.05). Both correlation coefficients indicate that any relationship between brain temperature and ICP accounts for less than 2% of the variability [coefficient of determination (r)<0.02].
CONCLUSIONS:
These data do not support the notion of a clinically useful correlation between brain temperature and ICP.
AuthorsGerald Huschak, Thomas Hoell, Martin Wiegel, Christian Hohaus, Ralph Stuttmann, Hans-Jörg Meisel, Henning Mast
JournalJournal of neurosurgical anesthesiology (J Neurosurg Anesthesiol) Vol. 20 Issue 2 Pg. 105-9 (Apr 2008) ISSN: 1537-1921 [Electronic] United States
PMID18362771 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Topics
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Body Temperature
  • Brain (physiopathology)
  • Brain Injuries (diagnosis, physiopathology)
  • Critical Care (methods)
  • Female
  • Fever (physiopathology)
  • Humans
  • Intracranial Pressure
  • Male
  • Middle Aged
  • Monitoring, Physiologic (methods)
  • Retrospective Studies
  • Time Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: