Histologic evaluation of a cornea in a patient with apolipoprotein A-I deficiency.

Abstract

PURPOSE:

To report the histology of a cornea in a patient with apolipoprotein A-I (apoA-I) deficiency.

METHODS:

A cornea from a patient with apoA-I deficiency was obtained by keratoplasty and examined histologically.

RESULTS:

There were many small vesicles in the extracellular matrix throughout the corneal stroma. The vesicles were round or oval, and their diameters ranged from 200 nm to 2 microm. These histologic properties suggest that the small vesicles are lipid droplets.

CONCLUSIONS:

Myriad lipid droplets in the extracellular matrix in the corneal stroma induce diffuse corneal opacity in a patient with apoA-I deficiency.

• Authors: Yasuhiro Osakabe, Shiro Amano, Shima Fukuoka, Satoru Yamagami
• Journal: Cornea (Cornea) Vol. 27 Issue 3 Pg. 372-3 (Apr 2008) ISSN: 0277-3740 [Print] United States
• PMID: 18362673 (Publication Type: Case Reports, Journal Article)

Chemical References

• Apolipoprotein A-I

Topics

• Aged
• Apolipoprotein A-I (deficiency, genetics)
• Cornea (ultrastructure)
• Corneal Opacity (etiology, pathology, surgery)
• Female
• Frameshift Mutation
• Humans
• Keratoplasty, Penetrating