Desmopressin increases IGF-binding protein-1 in humans.

Abstract

CONTEXT:

IGF binding protein-1 (IGFBP-1) is essential for IGF-I bioavailability. High levels of IGFBP-1 are encountered in critically ill patients and are a good predictor marker in acute myocardial infarction. The mechanisms responsible for the elevated IGFBP-1 levels in these conditions are still unclear. Interestingly, high levels of vasopressin have been reported in the above-mentioned conditions.

OBJECTIVE:

To study the effect of vasopressin on IGFBP-1 in humans.

DESIGN:

Placebo-controlled cross-over study in patients with central diabetes insipidus (CDI) in whom potential interference from endogenous vasopressin secretion is minimized. After a 3-day desmopressin washout period, each patient received i.v. saline on day 1 and desmopressin (3 mug) on day 2. Blood samples were taken after administration, every 2 h during the whole night, starting at 2000 h.

PATIENTS AND SETTING:

Fourteen inpatients with CDI in an endocrinology department of a university hospital.

RESULTS:

Serum IGFBP-1 increased within 4 h after 1-desamino-8-d-arginine vasopressin (DDAVP) by 375+/-73%, compared with a spontaneous fasting increase by 252+/-46% following placebo administration (P<0.05). No changes were registered in the levels of either classically regulators of IGFBP-1 (insulin, glucagon, and cortisol) or of IGF-I and glucose. The decrease in plasma osmolarity induced by DDAVP did not precede the increase in IGFBP-1.

CONCLUSIONS:

DDAVP increases serum levels of IGFBP-1. Further investigation is essential to unravel the clinical potential of this interaction in conditions associated with high IGFBP-1 levels.

• Authors: S B Catrina, R Rotarus, I R Botusan, M Coculescu, K Brismar
• Journal: European journal of endocrinology (Eur J Endocrinol) Vol. 158 Issue 4 Pg. 479-82 (Apr 2008) ISSN: 1479-683X [Electronic] England
• PMID: 18362294 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Antidiuretic Agents
• IGFBP1 protein, human
• Insulin
• Insulin-Like Growth Factor Binding Protein 1
• Placebos
• Glucagon
• Deamino Arginine Vasopressin
• Hydrocortisone

Topics

• Antidiuretic Agents (pharmacology, therapeutic use)
• Cross-Over Studies
• Deamino Arginine Vasopressin (pharmacology, therapeutic use)
• Diabetes Insipidus, Neurogenic (blood, drug therapy)
• Glucagon (blood)
• Humans
• Hydrocortisone (blood)
• Insulin (blood)
• Insulin-Like Growth Factor Binding Protein 1 (blood, metabolism)
• Placebos